Sorafenat 200 mg (Sorafenib)
Sorafenat 200 mg (Sorafenib) Tablet refers to the class of medicines known as tyrosine kinase inhibitors used to treat liver cancer, kidney cancer, and thyroid cancer.
- Category : Kidney Disease
- Manufacturer : Generic
- Active Substance : Sorafenib
- Customer Rate
- Prescription : Required or Will Provide upon Online Doctor Consultation
INTRODUCTION
SORAFENAT 200MG TABLET contains Sorafenib which belongs to the group of medicines called Multikinase inhibitors. It is used to treat liver cancer (hepatocellular carcinoma), and kidney cancer (advanced renal cell carcinoma) at an advanced stage when standard therapy has not helped to stop the disease or considered unsuitable. SORAFENAT 200MG TABLET is also used to treat differentiated thyroid cancer that is not responding to radioactive iodine treatment.
SORAFENAT 200MG TABLET is not recommended for use in patients with squamous cell lung cancer. SORAFENAT 200MG TABLET should be used with caution in patients with severe liver or kidney disease, high blood pressure, and heart diseases such as abnormal heart rhythm disorders like prolonged QT interval, diabetes, and bleeding problems. Consult your doctor before taking SORAFENAT 200MG TABLET
SORAFENAT 200MG TABLET is not recommended for use during pregnancy or if you think you could become pregnant, use adequate contraception during treatment with this medicine. SORAFENAT 200MG TABLET is not recommended for use in breastfeeding women as it interferes with the growth of the developing baby. Contact your doctor for advice before taking SORAFENAT 200MG TABLET
The safety and efficacy of SORAFENAT 200MG TABLET in children and adolescents aged below 18 years have not yet been established. SORAFENAT 200MG TABLET should be used with caution in elderly patients with kidney failure. Contact your doctor before taking SORAFENAT 200MG TABLET. The most common side effects of taking SORAFENAT 200MG TABLET are nausea, diarrhoea, vomiting, constipation, weakness or tiredness, hair loss (alopecia) or rash. Contact your physician if any of the symptoms worsen.
USES OF SORAFENAT 200MG TABLET
- Treats liver cancer (hepatocellular carcinoma)
- Treats kidney cancer (advanced renal cell carcinoma)
- Treats thyroid cancer (differentiated thyroid carcinoma)
HOW SORAFENAT 200MG TABLET WORKS
SORAFENAT 200MG TABLET is an oral multi-kinase inhibitor which blocks tumour cell growth. It targets several enzymes on the surface of cancer cells and also targets within the cell. Several of these targets are thought to be involved in angiogenesis (making of blood vessels). SORAFENAT 200MG TABLET works by slowing down the rate of growth of cancer cells and cutting off the blood supply that keeps cancer cells growing.
DIRECTIONS FOR USE
Take SORAFENAT 200MG TABLET as advised by your physician. Swallow the medicines with a glass of water. Do not crush or chew the medicine. Your physician will decide the correct dose and duration for you depending upon your age, body weight and disease condition.
SIDE EFFECTS OF SORAFENAT 200MG TABLET
COMMON
- Nausea
- Diarrhoea
- Vomiting
- Constipation
- Abdominal pain
- Weakness or tiredness
- Mouth pain, pain in bones, and tumour pain
- Hair loss (alopecia)
- Headache
- Itching or rash
- Redness or painful palms and soles
- Bleeding in the brain, lungs or airways, stomach and intestine
- High blood pressure
- Infections
- Loss of appetite
- Joint pain (arthralgia)
- Fever
- Weight loss
- Flu-like illness
- Indigestion
- Difficulty swallowing
- Inflamed or dry mouth
- Tongue pain
- Hypocalcaemia (decrease in calcium levels in the blood)
- Low blood sugar levels
- Hypokalaemia (decrease in potassium levels)
- Muscle pain
- Tingling and numbness sensations in fingers and toes
- Erection problems (impotence)
- Change in voice
- Acne
- Inflamed, dry, scaly skin or shedding
- Kidney failure
- Decrease in white blood cells (leukopenia)
- Decrease in red blood cells (anaemia)
- Decrease in platelet count (thrombocytopenia)
- Inflammation of hair follicles
- Hypothyroidism
- Hyponatremia (low sodium levels in the blood)
- Change in sense of taste
- Redness of the face and other areas of the skin (flushing)
- Runny nose
- Heartburn
- Skin cancer
- Thickening of the skin
- Muscle spasms
- Ringing in the ear
UNCOMMON
- Gastritis, abdominal pain caused by pancreatitis, inflammation of the gall bladder and/or bile ducts
- Yellowish discolouration of skin or white of the eyes (jaundice) caused by high levels of bile pigments (hyperbilirubinemia)
- Allergic reactions like skin reactions and hives
- Dehydration
- Enlargement of breasts
- Breathing difficulty
- Eczema
- Hyperthyroidism
- Multiple skin eruptions (erythema multiforme)
- Reversible posterior leukoencephalopathy (reversible swelling in the rear part of the brain that can be associated with headache, change in consciousness, fits and visual loss)
RARE
- Sunburn-like rash or severe radiation recall dermatitis may occur in patients with a history of radiotherapy treatment
- Abnormal heart rhythm (QT prolongation)
- Nephrotic syndrome (damage to the kidney causing leakage of proteins)
- Inflammation of the vessels in the skin causing skin rashes
- Allergic reaction such as swelling of the face, tongue causing difficulty in breathing or swallowing (angioedema)
- Serious reactions of the skin and/or mucous membranes include painful blisters, fever, and extensive detachment of the skin (Stevens-Johnson syndrome and toxic epidermal necrolysis)
- Breakdown of muscles (rhabdomyolysis) causing kidney problems
- Inflammation of the vessels in the skin which may result in skin rash (leucocytoclastic vasculitis)
Stop taking SORAFENAT 200MG TABLET and contact your physician immediately if you experience any of the following side effects:
- Severe allergic reactions (such as blisters, hives, skin swelling, face or tongue, difficulty breathing or swallowing, etc.)
- Symptoms of Tumour lysis syndrome (TLS) such as nausea, shortness of breath, irregular heartbeat, muscular cramps, seizure, clouding of urine and tiredness
- Rashes and skin reactions especially on the hands and feet
- Chest pain or heart problems such as heart attack
- Perforation or holes in the stomach or the intestine
- Severe bleeding which may also present as bloody vomit, brownish urine, red or black coloured stool, coughing up blood or blood clots, heavy menstrual bleeding, vaginal bleeding, bleeding from the nose etc.
- Severe diarrhoea
- Severe high blood pressure or liver injury
HOW TO MANAGE SIDE EFFECTS
Constipation
Eat fibre rich foods such as fresh fruits, vegetables, and cereals. Drink more water and exercise regularly. Contact your doctor if constipation did not improve.
Diarrhea
Drink lots of fluids, such as water or fruit juices to keep yourself hydrated. Do not take any medicine on your own for treating diarrhoea. Contact your doctor if diarrhoea did not improve.
Headache
Rest and relax. Drink plenty of fluids such as water or electrolytes and apply a pain-relieving balm on the head if necessary. Contact your doctor if your headache worsens.
Nausea And Vomiting
Take this medicine with, or just after meals. Stick to simple meals. Avoid eating oily or spicy foods. Contact your doctor if nausea and vomiting did not improve.
Skin Rash Or Itching
Avoid taking bath with hot water as it irritates the skin further and do not scratch the affected area. Use sunscreen and protective clothing when going outdoors. Contact your doctor if rashes worsen.
Stomach Pain
Try to rest and relax. Eat smaller meals but take them frequently. Keep a heating pad on your stomach. Contact your doctor if stomach pain worsens.
WARNING & PRECAUTIONS
PREGNANCY
CONTRAINDICATED
SORAFENAT 200MG TABLET is not recommended for use during pregnancy or if you think you could become pregnant, use adequate contraception during treatment with this medicine. Consult your doctor before taking SORAFENAT 200MG TABLET.
BREASTFEEDING
CONTRAINDICATED
SORAFENAT 200MG TABLET is not recommended for use in breastfeeding women as it interferes with the growth of the developing baby. Consult your doctor before taking SORAFENAT 200MG TABLET.
DRIVING AND USING MACHINES
USE WITH CAUTION
There is no evidence that SORAFENAT 200MG TABLET will affect the ability to drive or operate machines.
KIDNEY
USE WITH CAUTION
SORAFENAT 200MG TABLET should be used with caution in patients with poor kidney function. Consult your doctor before taking SORAFENAT 200MG TABLET.
LIVER
USE WITH CAUTION
SORAFENAT 200MG TABLET should be used with caution in patients with severe liver disease. Consult your doctor before taking SORAFENAT 200MG TABLET.
ALLERGY
CONTRAINDICATED
Do not take SORAFENAT 200MG TABLET if you are allergic to Sorafenib or any other ingredients of this medicine.
LUNGS
CONTRAINDICATED
SORAFENAT 200MG TABLET is not recommended for use in patients with squamous cell lung cancer. Consult your doctor before taking SORAFENAT 200MG TABLET.
HEART DISEASE
USE WITH CAUTION
SORAFENAT 200MG TABLET should be used with caution in patients with high blood pressure and heart diseases such as abnormal heart rhythm disorders called prolonged QT interval. Consult your doctor before taking SORAFENAT 200MG TABLET.
USE IN PEDIATRICS
CONSULT YOUR DOCTOR
The safety and efficacy of SORAFENAT 200MG TABLET in children and adolescents (below 18 years of age) have not yet been established. Consult child’s doctor for advice
USE IN GERIATRICS
USE WITH CAUTION
SORAFENAT 200MG TABLET should be used with caution in elderly patients with kidney failure. Consult your doctor before taking SORAFENAT 200MG TABLET.
OTHERS
Before taking SORAFENAT 200MG TABLET, inform your doctor if you have:
- Aneurysm (enlargement or weakening of blood vessels) or tearing of blood vessel wall
- Diabetes
- Bleeding problems
- Surgery, or recently had an operation
- Perforation of the stomach and intestine
- Low potassium, magnesium and calcium levels
INTERACTIONS
A. Drug-Drug interactions:
Before taking SORAFENAT 200MG TABLET, inform your doctor if you are taking any of the following medicines:
- Rifampicin, rifabutin, rifampin (used to treat tuberculosis)
- Neomycin or other antibiotics (used to treat bacterial infections)
- St. john’s wort (used to treat depression)
- Phenytoin, carbamazepine or phenobarbital (used to treat fits)
- Dexamethasone (used to treat inflammation)
- Warfarin or phenprocoumon, anticoagulants such as dabigatran (used to prevent blood clots)
- Doxorubicin, capecitabine, docetaxel, paclitaxel, gemcitabine, cisplatin and irinotecan (used to treat cancer)
- Digoxin (used to treat heart failure)
- Midazolam (used to treat seizures)
- Dextromethorphan (used to treat cough)
- Omeprazole (used to treat gastric ulcers)
B. Drug – Food interactions:
Do not take SORAFENAT 200MG TABLET with high fat meals, as this may make the medicine less effective. If you intend to have a high fat meal, take SORAFENAT 200MG TABLET at least 1 hour before or 2 hours after the meal. Consult your doctor for advice.
Overdosage:
If you or anyone else accidentally take too much of SORAFENAT 200MG TABLET, consult your doctor immediately or visit the nearby hospital. Symptoms of overdosage are severe diarrhoea and skin reactions.
SYNOPSIS
| Drug | : | Sorafenib |
| Pharmacological Category | : | Multikinase inhibitors |
| Therapeutic Indication | : | Liver Cancer, Kidney Cancer, Thyroid Cancer |
| Dosage Forms | : | Tablet |
MORE INFORMATION
- Keep SORAFENAT 200MG TABLET out of the sight and reach of children.
- Store at room temperature
FAQs ABOUT SORAFENAT 200MG TABLET
Q: How does SORAFENAT 200MG TABLET work?
A: SORAFENAT 200MG TABLET is an oral multi-kinase inhibitor which blocks tumour cell growth. It targets several enzymes on the surface of cancer cells and also targets within the cell. Several of these targets are thought to be involved in angiogenesis (making of blood vessels). SORAFENAT 200MG TABLET works by slowing down the rate of growth of cancer cells and cutting off the blood supply that keeps cancer cells growing.
Q: Does SORAFENAT 200MG TABLET affects fertility?
A: Yes, SORAFENAT 200MG TABLET reduces fertility in both men and women. Consult your doctor before taking SORAFENAT 200MG TABLET if you want to father a child or if you are a woman with childbearing potential. Your doctor may recommend you to use effective contraceptive measures during treatment with SORAFENAT 200MG TABLET
Q: What are the common side effects of taking SORAFENAT 200MG TABLET?
A: The most common side effects of taking SORAFENAT 200MG TABLET are nausea, diarrhoea, vomiting, constipation, feeling weak or tiredness, and hair loss (alopecia). Consult your physician if any of the symptoms worsen.
Q: For how long should I need to take SORAFENAT 200MG TABLET?
A: If SORAFENAT 200MG TABLET is well tolerated, then you should continue taking it for the duration as suggested by the doctor. However, if you experience any unusual reactions which bothers you talk to your doctor for advice
Q: Is SORAFENAT 200MG TABLET safe to use in patients with heart disease?
A: SORAFENAT 200MG TABLET should be used with caution in patients with high blood pressure and heart diseases such as abnormal heart rhythm disorders called prolonged QT interval. Consult your doctor before taking SORAFENAT 200MG TABLET
Sorafenat 200 mg (Sorafenib) Tablet refers to the class of medicines known as tyrosine kinase inhibitors used to treat liver cancer, kidney cancer, and thyroid cancer.
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